Misha Collins as Deadpool:

Deadpool breaks the fourth wall by talking about his own comic (sometimes even having copies of it somehow), referring to artists or writers or even the reader, and discussing comics in general. He is most known for, however, talking to the yellow narration bubbles that his comic has. There have been several theories as to what the boxes really are but no one other than Deadpool can see them in continuity and therefore many people in the Marvel Universe think Deadpool is crazy. Deadpool also references popular media culture in the comics such as video games, celebrities, social networking, and what’s going on with the real world at the time.